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Seroconversion following Heplisav-B, hepatitis B vaccine (recombinant), adjuvanted, in patients with end-stage renal disease at an urban safety net hospital.
- Source :
-
American Journal of Health-System Pharmacy . 2023 Supplement, Vol. 80, pS130-S134. 5p. - Publication Year :
- 2023
-
Abstract
- Purpose Heplisav-B is a novel recombinant adjuvanted vaccine for hepatitis B virus (HBV) that has been approved as a 2-dose regimen and shown to have similar seroconversion rates in healthy adults as single-antigen HBV vaccines. More data are needed to determine whether similarly high rates of seroconversion and immunity are observed in immunocompromised patient populations such as in patients with end-stage renal disease (ESRD) on hemodialysis. Methods Patients with ESRD who presented for emergency-only hemodialysis and either were HBV vaccine naive or had a hepatitis B surface antibody (anti-HBs) titer of less than 10 IU/mL received 3 standard 20-μg doses of Heplisav-B at week 0, week 4 (±2 weeks), and week 24 (±2 weeks), with anti-HBs titer measured at week 28 (±2 weeks). Results Thirty-two patients received at least one dose in the study timeframe, with 24 patients completing the vaccine series and measurement of anti-HBs titer. The mean age of the patients was 46 years, and 58% of patients were male. Of the 24 patients who completed the vaccine series, 20 (83%) seroconverted after the third dose. Three of the 4 patients who did not seroconvert after 3 doses were revaccinated with an additional 20-μg dose, and 2 of the 3 patients had an anti-HBs titer of greater than 10 IU/mL 4 weeks after this dose. Conclusion Patients with ESRD who received three 20-μg doses of recombinant HBV vaccine had a seroconversion rate of 83%, representing a similar seroconversion rate and fewer doses of vaccine as compared to the standard HBV vaccine regimen for patients with ESRD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TREATMENT of chronic kidney failure
*HEPATITIS B prevention
*HEPATITIS B
*VACCINATION
*VACCINES
*IMMUNIZATION
*IMMUNOGLOBULINS
*TIME
*ATTITUDE (Psychology)
*SEROCONVERSION
*URBAN hospitals
*COMPARATIVE studies
*SAFETY-net health care providers
*DESCRIPTIVE statistics
*HEPATITIS B vaccines
*HEMODIALYSIS
*NEEDS assessment
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 10792082
- Volume :
- 80
- Database :
- Academic Search Index
- Journal :
- American Journal of Health-System Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 173808265
- Full Text :
- https://doi.org/10.1093/ajhp/zxad022