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Functionalized Alkylidenecyclobutanes from a Cyclopent‐2‐enone Substrate via a Tandem Photochemical Transformation and an Allylic Substitution Protocol.
- Source :
-
Advanced Synthesis & Catalysis . 11/21/2023, Vol. 365 Issue 22, p4002-4007. 6p. - Publication Year :
- 2023
-
Abstract
- A four‐step metal‐free procedure is described for the transformation of 4‐hydroxy‐2‐methylcyclopent‐2‐enone derivatives into highly functionalized E‐alkylidenecyclobutanes featuring oxygenated tetrasubstituted centers. The key intermediate is a (cyclobutenyl)propane‐1,3‐diol diester, easily accessed via a tandem photochemical reaction, which undergoes an original Brønsted acid‐catalyzed allylic substitution reaction with alcohols to give the title products with ester‐protected primary alcohol side chains. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SUBSTITUTION reactions
*ALLYL alcohol
*ALCOHOL
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 365
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 173778112
- Full Text :
- https://doi.org/10.1002/adsc.202300798