A Case Report on Pemphigus Foliaceus - An Acquired Autoimmune Blistering Disease.

Pemphigus is a group of disease characterized by IgG antibodies directed against epidermal adhesion complexes (desmosomes) of keratinocytes, leading to loss of cell adhesion, a phenomenon called acantholysis. The term 'Pemphigus' is derived from Greek word 'Pemphix' that means blister or bubbles. Different types of Pemphigus have been identified based on clinical and histopathological characteristics. Among this pemphigus vulgaris and pemphigus foliaceus were discussed. The patient has fluid filled itchy lesions, multiple facial bullae and erosions all over the body. It was initially diagnosed as a PV, but the patient does not have any blisters on the oral or mucosal membrane and then the blisters were not painful. The patient feels itching on the blisters. Through this evaluation it clearly shows, that the patient is suffering due to PF. The PV and the PF can be treated with corticosteroids and immunosuppresants. In this case, the patient was treated with Inj. Dexamethasone, T.Azothioprine, T.Cetrizine, T.CPM Betamethasone cream and cetrimide cream. Rituximab has been used to treat severe forms with complete remissions in patients and was the firstline treatment in Europe and United States approved by European Academy of Dermatology and Venereology (EADV). The patient should be reviewed periodically to achieve the remission and avoid reaccurance of the disease. [ABSTRACT FROM AUTHOR]