Photocatalytic Dehalogenative Deuteration of Halides over a Robust Metal–Organic Framework.

Deuterium labelling of organic compounds is an important process in chemistry. We report the first example of photocatalytic dehalogenative deuteration of both arylhalides and alkylhalides (40 substrates) over a metal–organic framework, MFM‐300(Cr), using CD3CN as the deuterium source at room temperature. MFM‐300(Cr) catalyses high deuterium incorporation and shows excellent tolerance to various functional groups. Synchrotron X‐ray powder diffraction reveals the activation of halogenated substrates via confined binding within MFM‐300(Cr). In situ electron paramagnetic resonance spectroscopy confirms the formation of carbon‐based radicals as intermediates and reveals the reaction pathway. This protocol removes the use of precious‐metal catalysts from state‐of‐the‐art processes based upon direct hydrogen isotope exchange and shows high photocatalytic stability, thus enabling multiple catalytic cycles. [ABSTRACT FROM AUTHOR]