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Efficient synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative via multistep synthesis approach by novel Cu@Py-Oxa@SPION catalyst.
- Source :
-
BMC Chemistry . 11/14/2023, Vol. 17 Issue 1, p1-12. 12p. - Publication Year :
- 2023
-
Abstract
- In this pared, an efficient method is introduced for the synthesis of 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives. These novel products have both 1,2,3-triazole and quinazolinone in their structures. For the synthesis of these products, a novel catalyst is designed, synthesized, and characterized by the immobilization of copper onto modified magnetic iron oxide. The catalyst (denoted: Cu@Py-Oxa@SPION) was characterized by several characterization techniques. In this regard, 16 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized in high isolated yields (77–86%). As an advantage, the catalyst is highly recoverable and its activity has not decreased after 7 sequential runs. The method is very efficient for the synthesis of the products in high isolated yields under mild reaction conditions in a green solvent. The scope of the method is broad and several examples were successfully synthesized using starting materials with different functional groups. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CATALYSTS
*QUINAZOLINONES
*FERRIC oxide
*COPPER
*IRON oxides
*COPPER catalysts
Subjects
Details
- Language :
- English
- ISSN :
- 2661801X
- Volume :
- 17
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 173627038
- Full Text :
- https://doi.org/10.1186/s13065-023-01072-4