Pulsatile Dexamethasone Therapy Reduces Epileptic Burden and Improves Sleep Physiology in Children with Genetic Drug-Resistant Epilepsy.

This article, published in the journal Neuropediatrics, discusses a study on the use of pulsatile corticoid therapy (PCT) in children with genetic drug-resistant epilepsy. The study aimed to compare the epileptic burden in children before and after PCT treatment using objective and subjective approaches. The results showed that PCT led to a significant reduction in spike burden in the electroencephalogram (EEG) and improved sleep physiology, specifically an increase in fast spindle rates. Additionally, seizure frequency improved in the majority of patients, and no severe adverse effects were reported. The study suggests that PCT may be an effective treatment option for children with genetic drug-resistant epilepsy, leading to a reduction in epileptic burden and improvement in cognitive functioning. [Extracted from the article]