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Catalytic asymmetric transformation of nitrones and allenes to dihydropyridoindoles via chiral N,N′-dioxide/cobalt(II) catalysis.
- Source :
-
Chemical Communications . 5/4/2022, Vol. 58 Issue 36, p5482-5485. 4p. - Publication Year :
- 2022
-
Abstract
- A chiral N,N′-dioxide/cobalt(II) complex catalytic system is developed to promote the multistep cascade reaction of α,β-unsaturated-N-aryl nitrones with allenes, giving a variety of chiral dihydropyridoindoles in moderate to good yields with excellent dr and ee values. Mechanistic studies support a [3+2] cycloaddition/[3,3]-rearrangement/retro-Mannich process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DERACEMIZATION
*NITRONES
*ALLENE
*CATALYSIS
*COBALT
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 36
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 173555962
- Full Text :
- https://doi.org/10.1039/d2cc01263d