BONE MARROW CHANGES IN MEGAKARYOCYTES IN THROMBOCYTOPENIA -- A TERTIARY CARE CENTER STUDY.

BACKGROUND: Platelets play vital roles in repair of the minute vascular damages in day to day life, wound repair, the innate immune response and metastatic tumour cell biology. AIMS AND OBJECTIVES: The aim of our study was to examine bone marrow aspiration smears for changes in megakaryocytes in patients with thrombocytopenia. MATERIALS AND METHODS: It was a prospective study carried out from June 2022 to June 2023. A series of 53 bone marrow aspirates were examined in patients with thrombocytopenia to look for changes in megakaryocytes. RESULTS: Out of the 53 cases megakaryocytes were suppressed in 20 cases (37%), inadequate in 9 cases (17%), hypoactive in 11 cases (21%), absent in 6 cases (11.5%) and adequate in 7 cases (13.5%) of thrombocytopenia. In our study nutritional deficiency was the most common cause of thrombocytopenia. CONCLUSION: Peripheral blood and bone marrow examination is crucial for patients with thrombocytopenia. Understanding the morphological changes of megakaryocytes in bone marrow aspirates can improve the diagnostic accuracy. [ABSTRACT FROM AUTHOR]