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Synthesis and evaluation of Escitalopram-loaded niosomes on colon cancer cell lines.
- Source :
-
Physiology & Pharmacology . Sep2023, Vol. 27 Issue 3, p307-318. 12p. - Publication Year :
- 2023
-
Abstract
- Introduction: It has been approved that selective serotonin reuptake inhibitors (SSRIs) may exhibit anti-proliferative or cytotoxic effects on several types of cancers. The aim of the present study was to evaluate the cytotoxic effects of a newly formulated niosome of Escitalopram oxalate on a colorectal cancer cell line. Methods: The niosomes were prepared using a thin layer hydration method, resulting in particles with a size range between 150 – 450 nm and spherical morphology. Moreover, its permeability release showed 25% in 4 hours. The cytotoxicity evaluation was performed using a quantitative colorimetric MTT assay. Results: The cell viability of colon cancer cells after treatment with niosomes and pure escitalopram reduced to 28.3 ± 0.83 % and 24.07 ± 0.56%, respectively. However, the cytotoxicity assay of escitalopram-loaded niosomes suggested that the anti-proliferative effect of the niosomal formulation of escitalopram was dose and incubation time-dependent. Conclusion: These results confirm the potential of the anti-proliferative activity of escitalopram-loaded niosomes. Further application to an in vivo model is needed to study various pharmacokinetic and pharmacodynamics parameters to establish its complete therapeutic potential. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLON cancer
*CANCER cells
*CELL lines
*SEROTONIN uptake inhibitors
*CYTOTOXINS
Subjects
Details
- Language :
- English
- ISSN :
- 17350581
- Volume :
- 27
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Physiology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 173539498
- Full Text :
- https://doi.org/10.61186/phypha.27.3.307