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Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study.

Authors :
Caparros-Gonzalez, Rafael A.
Essau, Cecilia
Gouin, Jean-Philippe
Pemau, Andres
Galvez-Merlin, Alejandra
de la Torre-Luque, Alejandro
Source :
Journal of Perinatal Medicine. Nov2023, Vol. 51 Issue 9, p1163-1170. 8p.
Publication Year :
2023

Abstract

Asthma is a common chronic and burdensome disease which typically begins in childhood. The aim of this study was to assess perinatal and obstetric factors which may increase the risk of developing asthma in the offspring. Data from five consecutive waves (n=7,073 children, from birth to 15 years old) from a nationally-representative birth cohort of people born in the United Kingdom between 2000 and 2002, the Millennium Cohort Study (MCS), were used. The Kaplan–Meier survival curve was used to graphically display the risk of developing asthma from early childhood to adolescence. The Z-based Wald test was used to prove significant covariate loading. Cox regression analyzing the influence of covariates on asthma development risk showed a significant likelihood ratio test, χ2(18)=899.30, p<0.01. A parent with asthma (OR=2.02, p<0.01), a younger maternal age at delivery (OR=0.98, p<0.05), and the use of assisted reproductive technology (OR=1.43, p<0.05) were associated with an increased risk of developing asthma in the offspring. Perinatal factors (a younger maternal age, assisted reproductive technology) and a parental factor (a parent with asthma) increased the risk for developing asthma in the offspring. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03005577
Volume :
51
Issue :
9
Database :
Academic Search Index
Journal :
Journal of Perinatal Medicine
Publication Type :
Academic Journal
Accession number :
173491442
Full Text :
https://doi.org/10.1515/jpm-2022-0543