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Patient-reported persistent symptoms after radiotherapy and association with quality of life for prostate cancer survivors.

Authors :
Spampinato, Sofia
Rancati, Tiziana
Waskiewicz, Justyna Magdalena
Avuzzi, Barbara
Garibaldi, Elisabetta
Faiella, Adriana
Villa, Elisa
Magli, Alessandro
Cante, Domenico
Girelli, Giuseppe
Gatti, Marco
Noris Chiorda, Barbara
Rago, Luciana
Ferrari, Paolo
Piva, Cristina
Pavarini, Maddalena
Valdagni, Riccardo
Vavassori, Vittorio
Munoz, Fernando
Sanguineti, Giuseppe
Source :
Acta Oncologica. Nov2023, Vol. 62 Issue 11, p1440-1450. 11p.
Publication Year :
2023

Abstract

To evaluate the persistence of symptoms after radiotherapy (RT) for localised prostate cancer (PCa) and the association with quality of life (QOL). Prospective patient-reported outcome (PRO) from a multi-institutional study on PCa treated with radical RT (2010–2014) was analysed. Data was collected at baseline (BL) and follow-ups (FUPs) up to 5 years. Patients with BL and ≥3 late FUPs (≥6 months) were analysed. PRO was scored by means of the IPSS and ICIQ-SF (urinary), LENT-SOMA (gastrointestinal [GI]), and EORTC-C30 (pain, insomnia, fatigue, and QOL) questionnaires. Symptoms were defined 'persistent' if the median score over FUPs was ≥3 (urinary) or ≥2 (GI, pain, insomnia, and fatigue), and worse than BL. Different thresholds were chosen to have enough events for each symptom. QOL was linearly transformed on a continuous scale (0–100). Linear-mixed models were used to identify significant differences between groups with and without persistent symptoms including age, smoking status, previous abdominal surgery, and diabetes as confounders. Mean QOL differences between groups were evaluated longitudinally over FUPs. The analysis included 293 patients. Persistent urinary symptoms ranged from 2% (straining) to 12% (weak stream, and nocturia). Gastrointestinal symptoms ranged from 7% (rectal pain, and incontinence) to 30% (urgency). Proportions of pain, insomnia, and fatigue were 6, 13, and 18%. Significant QOL differences of small-to-medium clinical relevance were found for urinary incontinence, frequency, urgency, and nocturia. Among GI symptoms, rectal pain and incontinence showed small-to-medium differences. Fatigue was associated with the largest differences. The analysis showed that symptoms after RT for PCa occur with different persistence and their association with QOL varies in magnitude. A number of persistent urinary and GI symptoms showed differences in a comparable range. Urinary incontinence and frequency, rectal pain, and faecal incontinence more often had significant associations. Fatigue was also prevalent and associated with largely deteriorated QOL. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0284186X
Volume :
62
Issue :
11
Database :
Academic Search Index
Journal :
Acta Oncologica
Publication Type :
Academic Journal
Accession number :
173489562
Full Text :
https://doi.org/10.1080/0284186X.2023.2259597