常染色体显性遗传多囊肾病合并男性不育患者植入前遗传学检测的临床结局.

Objective: To investigate the clinical outcomes of preimplantation genetic testing (PGT) in patients with autosomal dominant polycystic kidney disease (ADPKD) associated with male infertility. Methods: From March 2020 to December 2021, 7 patients with ADPKD associated with male infertility were conducted PGT treatment in the center for reproduction and genetics of the Affiliated Suzhou Hospital of Nanjing Medical University. Data on imaging, sperm quality, sperm ultrastructure, genetic etiology, and preimplantation genetic analysis were retrospectively analyzed. Results: All 7 patients showed different degrees of oligozoospermia, and the PKD1 gene heterozygous mutation. The majority of patients showed dilatation or cystic lesions of the reproductive tract, and the disturbed partially ultrastructure of sperm flagellum. Five clinical pregnancies and successful births were achieved after assisted reproduction in 7 patients. Conclusions: The results of genetic testing can guide the treatment in patients with ADPKD associated with male infertility, and PGT can improve pregnancy outcomes. [ABSTRACT FROM AUTHOR]