小脳髄芽腫治療後に発生した膠芽腫の 分子病理学的解析の導入.

The number of long-term survivors of pediatric medulloblastoma has been increasing due to improved treatment options. However, secondary cancer can be an issue for long-term survivors. Of the 27 patients with cerebellar medulloblastoma treated at our institution, two developed cerebellar glioblastomas after the initial treatment at five years and 11 months and 22 years and eight months, respectively. These two cerebellar glioblastomas were clinically diagnosed as radiation-induced secondary cancer. Both of the two cases we clinically diagnosed as radiation-induced glioblastoma had negative IDH-1, EGFR expression and positive p53 expression in immunohistochemistry, and the molecular evaluation was consistent with radiation-induced secondary cancer. [ABSTRACT FROM AUTHOR]