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Ang-2 is a potential molecular marker for lymphatic metastasis and better response to bevacizumab therapy in ovarian cancer.

Authors :
Volk, Annabelle
Legler, Karen
Hamester, Fabienne
Kuerti, Sascha
Eylmann, Kathrin
Rossberg, Maila
Schmalfeldt, Barbara
Oliveira-Ferrer, Leticia
Source :
Journal of Cancer Research & Clinical Oncology. Dec2023, Vol. 149 Issue 17, p15957-15967. 11p.
Publication Year :
2023

Abstract

Purpose: In ovarian cancer, there are two main routes of metastasis, namely intraperitoneal and retroperitoneal. Their biologic background is poorly understood. Identifying molecular markers involved might enable the development of tailored therapy regimens. Moreover, no reliable markers for response to anti-angiogenic treatment with bevacizumab are yet established. Angiopoietin-2 (Ang-2) is an angiogenic growth factor, involved in lymphatic activation and is associated with tumor progression. Here, we assessed the potential of Ang-2 as a molecular marker in metastasis and treatment of ovarian cancer. Methods: In our study, quantitative and qualitative protein Ang-2 expression in tumor tissue of ovarian cancer patients was analyzed by Western blot (n = 138) and immunohistochemistry (n = 58). Further, Ang-2 levels in blood samples were quantified in enzyme-linked immunosorbent assay (n = 38). Expression levels of different tumor spread patterns were evaluated, and survival analyses were made. Results: We observed that Ang-2 expression is significantly higher in tumors with retroperitoneal dissemination (pT1a–pT3b, pN1) compared to those showing intraperitoneal tumor growth (pT3c, pN0). In addition, patients with high Ang-2 expression have significantly longer overall survival compared to patients with low Ang-2 expression. Patients with high Ang-2 expression benefit significantly from therapy with bevacizumab. Conclusion: All in all, Ang-2 may serve as a molecular marker for patients with tumors prone to spread to lymph nodes and for patients who might benefit from bevacizumab therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01715216
Volume :
149
Issue :
17
Database :
Academic Search Index
Journal :
Journal of Cancer Research & Clinical Oncology
Publication Type :
Academic Journal
Accession number :
173396343
Full Text :
https://doi.org/10.1007/s00432-023-05354-1