除幽愈疡免煎颗粒联合含铋剂四联疗法对 Hp 感染 相关慢性胃炎患者 Hp 根除率及炎症因子的影响Δ.

OBJECTIVE: To probe into the effects of Chuyou Yuyang Mianjian granules combined with bismuth quadruple therapy on Helicobacter pylori (Hp) eradication rate and inflammatory factors in patients with HP infection)associated chronic gastritis, so as to provide reference for promoting the outcome of Hp infection-associated chronic gastritis. METHODS: In this prospective randomized controlled study, 96 patients with Hp infection-associated chronic gastritis admitted into the hospital from Mar. 2020 to Feb. 2022 were extracted to be equally divided into the observation and control groups via the random number table method, with 48 cases each group. The control group received bismuth quadruple therapy, while the observation group was additionally treated with Chuyou Yuyang Mianjian granules on the basis of the control group, with 14 d as a course of treatment for both groups. The evaluation items included the clinical effect, inflammatory factors [ serum interleukin ( IL)-1β, IL-6, IL-8, tumor necrosis factor α (TNF-α), nuclear transcription factor κB (NF-κB)], adverse drug reactions and HP eradication rate during one course of treatment. RESULTS: During the treatment period, two patients in the observation group were excluded due to did not follow the medical orders, and one patient in the control group was excluded due to the use of non-research drugs. Totally 46 cases in the observation group and 47 cases in the control group were enrolled as the actual study subjects. There was no significant difference in the total effective rate between the observation group and the control group [89. 13% (41 / 46) vs. 80. 85% (38 / 47),P>0. 05]. In terms of improvement degree, the clinical recovery rate of the observation group was 39. 13% (18 / 46), significantly higher than 23. 40% (11 / 47) of the control group, with statistically significant differences (P<0. 05). During one course of treatment, the serum levels of IL-1β, IL-6, IL-8, TNF-α and NF-κB in two groups were lower than those before treatment, and the above indexes in the observation group were significantly lower than those in the control group, with statistically significant differences (P< 0. 05). There was no statistical significant difference between two groups in terms of safety indexes and adverse drug reactions (P>0. 05). Results of 14C-UBT test showed that the Hp eradication rate in the observation group was higher than that in the control group, the difference was statistically significant (P<0. 05). CONCLUSIONS: Chuyou Yuyang Mianjian granules combined with bismuth quadruple therapy in the treatment of patients with Hp infection-associated chronic gastritis can effectively inhibit the inflammatory response and improve the Hp eradication rate without increasing adverse drug reactions, which is helpful to promote the outcome of the disease. [ABSTRACT FROM AUTHOR]