从毒损络脉论治运动神经元病.

Motor neuron disease (MND), a clinical refractory disease, can be classified as “a disease of flaccidity and spasticity” in traditional Chinese medicine ( TCM). Many doctors have their own ideas regarding the treatment of syndrome differentiation, but there is no clear consensus. The concept of toxins damaging collaterals was developed from the theory of “toxins damaging brain collaterals” put forward by academicia Wang Yongyan, which marks the pathological process of toxicity accumulation and toxicity to collaterals, causing the spread of toxicity, directly damaging the shape and quality of the zang-fu organs and resulting in rapid deterioration of the disease. Combined with the theory of TCM and modern research, the pathological changes of toxins damaging collaterals are consistent with the characteristics of occult, extensive, and intractable lesions of MND. It is suggested that toxins damaging collaterals may be the core pathogenesis of the occurrence and development of MND, namely, the accumulation of toxins from external contraction and internal damage in the medullary collaterals leads to damage to the medullary collaterals, imbalance of qi and blood, metabolic imbalance, and subsequent brain and spinal cord injuries, leading to MND. Moreover, qi deficiency and internal wind-related pathogenesis are extended from toxins damaging collaterals. Qi deficiency and toxins damaging collaterals influence each other, leading to the worsening of disease. Wind images of MND muscles may be induced by toxins damaging collaterals. Therefore, the treatment principle of detoxifying and regulating collaterals to remove evil, replenishing qi, and nourishing yin to solidify the root is put forward, emphasizing supplementing qi and detoxifying, nourishing yin and dispelling wind, and regulating collaterals, in order to expand the options for MND treatment and further improve the clinical effect. [ABSTRACT FROM AUTHOR]