丁苯酞治疗脑小血管病致脑卒中后认知功能障碍的疗效及对 脑部血流灌注的影响.

Objective To investigate the effect of butylphthalide on cognitive dysfunction after the stroke caused by cerebral small vessel disease and its effect on cerebral blood perfusion. Methods　84 patients with the cognitive impairment after the stroke caused by small vessel disease were retrospectively selected from the Neurology Department of Shijiazhuang People’s Hospital from March 2019 to March 2021. According to the different treatment methods, they were divided into the control group (basic treatment) and the study group (basic treatment+butylphthalide treatment), with 42 patients in each group. Cognitive function, daily living ability, neurological function deficits, and changes in cerebral blood flow perfusion were observed. Results After 3 months of treatment，MMSE and Barthel index scores increased and NIHSS scores decreased in the two groups (P < 0.05). After the treatment，MMSE and Barthel index scores in the study group were higher than those in the control group (P < 0.05). The mean passage time of patients in the two groups decreased，and the CEREBRAL blood flow and blood flow velocity increased. In comparison with the results between the two groups，the mean passage time of patients in the study group was lower than that of the control group after the treatment，while the cerebral blood flow and blood flow velocity were significantly higher than that of the control group (P < 0.05). Conclusion Butylphthalide can improve the cerebral blood flow perfusion and promote the recovery of patients’ cognitive function and daily living ability in the treatment of cognitive dysfunction after the stroke caused by cerebral small vascular disease. [ABSTRACT FROM AUTHOR]