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Estrogen attenuates hypoxic–ischemic brain injury in neonatal rats
- Source :
-
European Journal of Pharmacology . Jan2005, Vol. 507 Issue 1-3, p77-86. 10p. - Publication Year :
- 2005
-
Abstract
- Abstract: Estrogen is neuroprotective in adult animals. We wished to determine if estrogen protects against brain injury in the newborn. Four-day-old rat pups were treated with subcutaneously implanted pellets containing 0.05 mg (2.4 μg/day) of 17β-estradiol or vehicle, designed to release the estrogen over 21 days. At 7 days old the pups had the right carotid artery ligated followed by 2.5 h of 8% oxygen. Brain damage was evaluated by weight deficit of the right hemisphere at 22 days following hypoxia. Estradiol treatments reduced brain weight loss from −17.4±2.8% S.E.M. in the vehicle group (n=32) to −9.3±2.7% in the treated group (n=32, P<0.05). Brain cortex thiobarbituric acid reacting substances and caspase activities were assessed 24 h after reoxygenation. Estradiol significantly reduced a hypoxia-induced increase in brain thiobarbituric acid reactive substances (P<0.05). Levels of caspase-3, -8 and -9 activity increased due to hypoxia–ischemia. Estradiol had no effect on caspase activity. Estradiol reduced brain injury in the neonatal rat. [Copyright &y& Elsevier]
- Subjects :
- *ESTROGEN
*CEREBROVASCULAR disease
*STEROID hormones
*ESTRADIOL
Subjects
Details
- Language :
- English
- ISSN :
- 00142999
- Volume :
- 507
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17309641
- Full Text :
- https://doi.org/10.1016/j.ejphar.2004.11.039