Back to Search Start Over

Design, synthesis, and evaluation of 1,2,3‐triazole‐based benzenesulfonamide and flavonol hybrid molecules as anticancer agents.

Authors :
Chen, Yu‐Xun
Chang, Chuan‐Hsin
Li, Cai‐Wei
Chen, Jih‐Jung
Shih, Tzenge‐Lien
Source :
Journal of the Chinese Chemical Society. Oct2023, Vol. 70 Issue 10, p1924-1936. 13p.
Publication Year :
2023

Abstract

Background: The design and synthesis of hybrid molecules will explore finding new drugs. Objectives: The synthesized hybrid molecules to evaluate their biological properties. Methods: Apply click chemistry to tether flavonols and benzenesulfonamide. Results: Two drug candidates show potential against lung cancer. Conclusions: Two drug candidates did not affect the normal cells and provided a new drug design route. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00094536
Volume :
70
Issue :
10
Database :
Academic Search Index
Journal :
Journal of the Chinese Chemical Society
Publication Type :
Academic Journal
Accession number :
173054614
Full Text :
https://doi.org/10.1002/jccs.202300279