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TXNDC12 knockdown promotes ferroptosis by modulating SLC7A11 expression in glioma.
- Source :
-
CTS: Clinical & Translational Science . Oct2023, Vol. 16 Issue 10, p1957-1971. 15p. - Publication Year :
- 2023
-
Abstract
- Ferroptosis is an iron‐dependent cell death process mainly triggered by reactive oxygen species (ROS) and lipid peroxidation. Thioredoxin domain protein 12 (TXNDC12) promotes the development of some tumors; however, its function in tumor ferroptosis remains unclear. In this study, we found that knockdown of TXNDC12 promoted erastin‐induced increase in ROS, lipid peroxidation, and Fe2+ levels, and decreased glutathione content. TXNDC12 is involved in ferroptosis by regulating SLC7A11. Further studies showed that TXNDC12 knockdown promoted an erastin‐induced decrease in glioma cell viability. Overall, TXNDC12 played a significant role in ferroptosis by modulating SLC7A11 expression. Thus, TXNDC12 and ferroptosis may provide new targets for the treatment of gliomas. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17528054
- Volume :
- 16
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- CTS: Clinical & Translational Science
- Publication Type :
- Academic Journal
- Accession number :
- 173054077
- Full Text :
- https://doi.org/10.1111/cts.13604