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Cerebrospinal Fluid Flow in Patients with Huntington's Disease.

Authors :
Hett, Kilian
Eisma, Jarrod J.
Hernandez, Adreanna B.
McKnight, Colin D.
Song, Alexander
Elenberger, Jason
Considine, Ciaran
Donahue, Manus J.
Claassen, Daniel O.
Source :
Annals of Neurology. Nov2023, Vol. 94 Issue 5, p885-894. 10p.
Publication Year :
2023

Abstract

Objective: Investigations of cerebrospinal fluid (CSF) flow aberrations in Huntington's disease (HD) are of growing interest, as impaired CSF flow may contribute to mutant Huntington retention and observed heterogeneous responsiveness to intrathecally administered therapies. Method: We assessed net cerebral aqueduct CSF flow and velocity in 29 HD participants (17 premanifest and 12 manifest) and 51 age‐ and sex matched non‐HD control participants using 3‐Tesla magnetic resonance imaging methods. Regression models were applied to test hypotheses regarding: (i) net CSF flow and cohort, (ii) net CSF flow and disease severity (CAP‐score), and (iii) CSF volume after correcting for age and sex. Results: Group‐wise analyses support a decrease in net CSF flow in HD (mean 0.14 ± 0.27 mL/min) relative to control (mean 0.32 ± 0.20 mL/min) participants (p = 0.02), with lowest flow in the manifest HD cohort (mean 0.04 ± 0.25 mL/min). This finding was explained by hyperdynamic CSF movement, manifesting as higher caudal systolic CSF flow velocity and higher diastolic cranial CSF flow velocity across the cardiac cycle, in HD (caudal flow: 0.17 ± 0.07 mL/s, cranial flow: 0.14 ± 0.08 mL/s) compared to control (caudal flow: 0.13 ± 0.06 mL/s, cranial flow: 0.11 ± 0.04 mL/s) participants. A positive correlation between cranial diastolic flow and disease severity was observed (p = 0.02). Interpretations: Findings support aqueductal CSF flow dynamics changing with disease severity in HD. These accelerated changes are consistent with changes observed over the typical adult lifespan, and may have relevance to mutant Huntington retention and intrathecally administered therapeutics responsiveness. ANN NEUROL 2023;94:885–894 [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03645134
Volume :
94
Issue :
5
Database :
Academic Search Index
Journal :
Annals of Neurology
Publication Type :
Academic Journal
Accession number :
173054002
Full Text :
https://doi.org/10.1002/ana.26749