9 个城市 112 家医院门急诊患者孕激素类药物 临床应用的处方大数据分析.

OBJECTIVE: To probe into the application status and rationality of progestogens in outpatient and emergency patients in China based on big data analysis techniques, so as to provide support for promoting clinical rational drug use and ensuring drug safety for patients. METHODS: Data of progestogen prescriptions from 2016 to 2020 were extracted from 112 hospitals in 9 cities. The application status of progestogens in China was analyzed, the composition and selection of progestogen for typical diseases were analyzed, and the problem of off-label indications was discussed. RESULTS: Totally 540 184 prescriptions were enrolled, including 605 233 records of progestogens. Except for 2020, which may be affected by COVID-19, the overall use and frequency of progestogens were on the increase, and the defined daily cost of high-priced progestogens decreased significantly since 2017. Progestin and dydrogesterone were the most widely used, and the latter had an obvious trend of increasing in clinical selection. Drug combination of progestogens were common (10. 9%, 58 625 cases). The applications of progestogens in patients with typical diseases had their own characteristics, and the drug selection was basically rational. Off-label indications were also common, and the most common diagnoses were endometrial polyps, gynecological examination and vaginitis. CONCLUSIONS: Progestogens are widely used in China and show an increasing trend, and the clinical application is basically reasonable, yet the problem of off-label indication drug use and the lack of evidence for drug combination deserve attention. In the future, it is still necessary to carry out high-quality clinical studies with large samples to verify the safety, effectiveness and economy of the use of progestogens. [ABSTRACT FROM AUTHOR]