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بررسی اثرات ویتامین C و اینوزیتول بر آسیب تخمدان و رحم ناشی از سیس پلاتین در موش صحرایی.
- Source :
-
Journal of Mazandaran University of Medical Sciences (JMUMS) . 2023, Vol. 33 Issue 225, p58-72. 15p. - Publication Year :
- 2023
-
Abstract
- Background and purpose: Cisplatin is one of the widely used chemotherapeutics, that directly affects the ovaries and uterus leading to infertility. This study aimed to investigate the effects of inositol and vitamin C on cisplatin-induced damage to ovarian follicles and uterine histopathology. Materials and methods: Fifty-six adult Wistar female rats were divided into eight equal groups (N=7) including negative control (oral normal saline/intraperitoneal normal saline), positive control (normal saline/cisplatin), T1 (vitamin C/cisplatin), T2 (inositol/cisplatin), T3 (vitamin C and inositol/cisplatin), T4 (vitamin C/normal saline), T5 (inositol/normal saline), and T6 (vitamin C and inositol/normal saline). The vitamin C and inositol were administered orally for 21 days. Cisplatin was injected intraperitoneally on the 15th day (7 mg/kg). On the day 22, the animals were euthanized, the uterus and ovaries removed, then the number of ovarian follicles and the uterine histopathology were examined. Results: After cisplatin treatment, the number of healthy ovarian follicles (primordial and antral) significantly decreased (P<0.05) compared to the negative control group. However, all of the atretic follicles increased compared to the negative control (P<0.05). Treatment with vitamin C and inositol increased the number of healthy follicles, effectively reduced the number of atretic follicles, and improved the damage induced by cisplatin in the uterine tissue. Conclusion: Treatment with vitamin C and inositol has a protective effect on the ovaries and uterus against the toxicity caused by cisplatin. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Persian
- ISSN :
- 17359260
- Volume :
- 33
- Issue :
- 225
- Database :
- Academic Search Index
- Journal :
- Journal of Mazandaran University of Medical Sciences (JMUMS)
- Publication Type :
- Academic Journal
- Accession number :
- 173022283