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Cyclopentadienyl and indenyl ruthenium(II) complexes containing diazafluorenone derivative ligands: Syntheses, characterization, antibacterial and cytotoxicity studies.
- Source :
-
Journal of Organometallic Chemistry . Nov2023, Vol. 1001, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- • Ruthenium cationic complexes derived from diazafluorenone derivative ligands. • CpRu(II) complexes showed better antimicrobial and anticancer activity. • Complex 1 showed the highest cytotoxicity towards DL cell line. We have successfully synthesized a series of eight versatile, half-sandwich ruthenium(II) cationic complexes [(Cp/Ind)Ru(к2 (N∩N) L)(PPh 3)]PF 6 (1–8), where L represents a 4,5-diazafluorenone derivative ligand. These complexes were isolated as their hexafluorophosphate salts and subjected to thorough characterization using various spectroscopic techniques such as FT-IR, NMR, UV and Mass. Furthermore, single-crystal X-ray diffraction studies determined the molecular structures of representative complexes 1, 7 , and 8. We screened the synthesized complexes and ligands in vitro to assess their potential antibacterial activity against three bacterial strains: the Gram-positive Staphylococcus aureus , the Gram-negative Escherichia coli and Klebsiella pneumoniae. Remarkably, all the compounds exhibited potent antibacterial activity against the tested organisms. In addition, we conducted a cell viability assessment to evaluate the cytotoxicity of the free ligands. The results indicated that the ligands did not demonstrate statistically significant cytotoxicity. However, it is noteworthy that complex 1 displayed more pronounced cytotoxic effects on the DL cell line, followed by complexes 3, 5 , and 7. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022328X
- Volume :
- 1001
- Database :
- Academic Search Index
- Journal :
- Journal of Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 173011400
- Full Text :
- https://doi.org/10.1016/j.jorganchem.2023.122876