Two new isostructural lanthanide metal-organic frameworks based on 2,5-furandicarboxylic acid for highly efficient sensing of lysophosphatidic acid.

Ovarian cancer (OC) is a serious health concern that is highly prevailing in women. In this regard, lysophosphatidic acid (LPA) is used as a biomarker for OC, and hence its early detection can help in a better treatment plan and cure of the disease. Thus, two new lanthanide metal-organic frameworks [Eu 2 (FDA) 3 (DMF) 2 (MeOH) 2 ] n (Eu-MOF) and [Tb 2 (FDA) 3 (DMF) 2 (MeOH) 2 ] n (Tb-MOF) were synthesized by using 2,5-furandicarboxylic acid as ligand under solvothermal method, which were in turn applied for the detection of LPA. Single-crystal X-ray diffraction indicated that both the Eu-MOF and Tb-MOF were isomorphic with tfz-d topology of {43} 2 {46.618.84} based on binuclear second building units to form 3D framework. Meanwhile, Eu-MOF realized highly selective detection for LPA through a strong fluorescence quenching with K SV = 1.17 × 104 M−1, effectively identified LPA compared to other major components of plasma. These findings conclude that Eu-MOF can be counted as a potential contender as a fluorescent sensor for the detection of LPA which can in turn help the early diagnosis of OC. Two new lanthanide metal-organic frameworks [Eu 2 (FDA) 3 (DMF) 2 (MeOH) 2 ] n (Eu-MOF) and [Tb 2 (FDA) 3 (DMF) 2 (MeOH) 2 ] n (Tb-MOF) with 3,8-connected tfz-d topology were synthesized and characterized. Eu-MOF has the best recognition effect to identify LPA with K sv of 1.17 × 104 M−1, and has good anti-interference properties compared to other analytes of plasma. These results conclude it is a promising material for detecting LPA to achieve early diagnosis of ovarian cancer. [Display omitted] • Two MOFs were synthesized and characterized. • The co-doped samples were prepared. • They can be used as fluorescence sensors for LPA. [ABSTRACT FROM AUTHOR]