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Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender.

Authors :
Maddalon, Ambra
Cari, Luigi
Iulini, Martina
Alhosseini, Mahdieh Naghavi
Galbiati, Valentina
Marinovich, Marina
Nocentini, Giuseppe
Corsini, Emanuela
Source :
Archives of Toxicology. Dec2023, Vol. 97 Issue 12, p3129-3150. 22p.
Publication Year :
2023

Abstract

Humans can be exposed to endocrine disruptors (EDs) in numerous ways. EDs can interfere with endogenous hormones at different levels, resulting in numerous adverse human health outcomes, including immunotoxicity. In this regard, this study aimed to investigate in vitro the possible effects of EDs on immune cells and possible gender differences. Peripheral blood mononuclear cells from healthy humans, both males and females, were exposed to 6 different EDs, namely atrazine (herbicide), cypermethrin (insecticide), diethyl phthalate (plasticizer), 17α-ethynylestradiol (contraceptive drug), perfluorooctanesulfonic acid (persistent organic pollutant), and vinclozolin (fungicide). We evaluated the effect of EDs on RACK1 (receptor for activated C kinase 1) expression, considering it as a bridge between the endocrine and the immune system, and putatively used as screening tool of immunotoxic effects of EDs. The exposure to EDs resulted at different extent in alteration in RACK1 expression, pro-inflammatory activity, natural killer lytic ability, and lymphocyte differentiation, with sex-related differences. In particular, diethyl phthalate and perfluorooctanesulfonic acid resulted the most active EDs tested, with gender differences in terms of effects and magnitude. The results from our study evidenced the ability of EDs to directly affect immune cells. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03405761
Volume :
97
Issue :
12
Database :
Academic Search Index
Journal :
Archives of Toxicology
Publication Type :
Academic Journal
Accession number :
172916726
Full Text :
https://doi.org/10.1007/s00204-023-03592-3