Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid.

The current review highlighted the synthesis and biological activities of bicyclic pyridines integrated steroid hybrid. The synthetic approaches, the proposed mechanisms, and biological activities were described. [Display omitted] • A comprehensive review on steroidal bicyclic pyridines. • Synthetic strategies for the annulation of binary and fused heterosteroids. • The proposed mechanisms were discussed for the synthesis of bicyclic systems. • Diverse biological activities and SAR's of steroidal bicyclic pyridines. Reports on structural modification of heterosteroids through various reactions, and developed synthetic routes have considerably increased over the last decade. The present review encompasses the applicable approaches dealing with the utility of reactive moieties in various steroids for the synthesis of fused bicyclic pyridines, and binary bicyclic pyridines all over the years. The different sections include the synthesis of steroids-fused, and binary quinolines, pyridopyrimidines, imidazopyridines, spirocyclic imidazopyridines, pyrazolopyridines, thienopyridines, pyridinyl-thiazoles, and tetrazolopyridine hybrids, as well as, the diverse biological applications of these heterocyclic steroids. The researchers' interest was principally focused on investigating the flexibility of synthetic strategies for various derivatives of natural steroids and building proposals based on heterocyclic steroids for drug discovery, biological assessments, and synthetic applications. [ABSTRACT FROM AUTHOR]