A case of pazopanib-induced acute kidney injury, reversible hair depigmentation and radiation recall dermatitis.

Abnormal crosstalk between endothelial cells and podocytes mediates TKI-induced proteinuria and kidney injury I via i blockage of VEGF receptors and their signaling. The patient presented with sunitinib-induced AEs, and his serum creatinine level gradually increased from 123 mol/L (initiation of sunitinib) to 203 mol/L, along with hypertension, 2+ proteinuria, and trace glycosuria. Dear Editor, Pazopanib is a multitargeted tyrosine kinase inhibitor (TKI) that acts against vascular endothelial growth factor (VEGF), platelet-derived growth factor, fibroblast growth receptor, and c-Kit [[1]]. [Extracted from the article]