PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.

The article focuses on how cells protect themselves from self-damage caused by interferon-stimulated genes (ISGs), specifically guanylate-binding proteins (GBPs), in response to interferon-g (IFN-g) stimulation, and how the kinase PIM1 controls GBP1 activity to prevent cellular damage while maintaining its antimicrobial function in human macrophages.