Small and Smart: Adventures in Epihalohydrin Chemistry.

Cyclizations, epoxides, regioselectivity, silyl enol ethers, epihalohydrins, dianions They possess three electrophilic centers and can undergo nucleophilic substitution reactions at the halide or ring-opening reactions at the epoxide moiety. In 2000, on the basis of the known cyclization of 1,3-dicarbonyl dianions with epoxides, [18] my student Tobias -Eckardt developed a related cyclization of epoxides with 1,3-bis(silyloxy)-1,3-butadienes. Keywords: cyclizations; dianions; epoxides; regioselectivity; silyl enol ethers; epihalohydrins EN cyclizations dianions epoxides regioselectivity silyl enol ethers epihalohydrins 1953 1960 8 10/09/23 20231024 NES 231024 Graph 1 Introduction Epichlorohydrin is a bulk chemical (800,000 t/a) that is used technically for the synthesis of epoxy resins and other polymers. [Extracted from the article]