Highlights of the 35th EANM Annual Congress 2022, onsite edition in Barcelona, Spain: "FROM BARCELONA WITH LOVE".

Keywords: EANM2022; Annual Congress; Abstracts; Nuclear medicine; Highlight; Top oral presentations EN EANM2022 Annual Congress Abstracts Nuclear medicine Highlight Top oral presentations 3168 3176 9 10/04/23 20230901 NES 230901 The original online version of this article was revised due to a retrospective Open Access cancellation. Patients with advanced solid tumors with three or more therapy lines were selected and planar and SPECT/CT scans performed at 4, 24, 48, and 168 h after each dose in each cycle to calculate organ and tumor dosimetry. They identified solitary fibrous tumors as the tumor type with the highest FAP expression and went on with a prospective imaging study with 38 patients that confirmed high or intermediate expression in 66% of the patients. Applied to a glioblastoma model in mice and to human glioblastoma tissues ex vivo submitted to TSPO PET radiotracers, they surprisingly observed that the radiotracer uptake was more intense in tumor cells than in immune cells, and significantly more elevated in single tumor cells of high-grade glioma compared to low-grade glioma patients (Fig. [Extracted from the article]