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Unsupervised [18F]Flortaucipir cutoffs for tau positivity and staging in Alzheimer's disease.
- Source :
-
European Journal of Nuclear Medicine & Molecular Imaging . Sep2023, Vol. 50 Issue 11, p3265-3275. 11p. 1 Color Photograph, 1 Chart, 2 Graphs. - Publication Year :
- 2023
-
Abstract
- Purpose: Several [18F]Flortaucipir cutoffs have been proposed for tau PET positivity (T+) in Alzheimer's disease (AD), but none were data-driven. The aim of this study was to establish and validate unsupervised T+ cutoffs by applying Gaussian mixture models (GMM). Methods: Amyloid negative (A−) cognitively normal (CN) and amyloid positive (A+) AD-related dementia (ADRD) subjects from ADNI (n=269) were included. ADNI (n=475) and Geneva Memory Clinic (GMC) cohorts (n=98) were used for validation. GMM-based cutoffs were extracted for the temporal meta-ROI, and validated against previously published cutoffs and visual rating. Results: GMM-based cutoffs classified less subjects as T+, mainly in the A− CN (<3.4% vs >28.5%) and A+ CN (<14.5% vs >42.9%) groups and showed higher agreement with visual rating (ICC=0.91 vs ICC<0.62) than published cutoffs. Conclusion: We provided reliable data-driven [18F]Flortaucipir cutoffs for in vivo T+ detection in AD. These cutoffs might be useful to select participants in clinical and research studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALZHEIMER'S disease
*GAUSSIAN mixture models
*OPTIMISM
Subjects
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 50
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 172445098
- Full Text :
- https://doi.org/10.1007/s00259-023-06280-7