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Ropinirole in treatment-resistant depression: a 16-week pilot study.
- Source :
-
Canadian Journal of Psychiatry . May2005, Vol. 50 Issue 6, p357-360. 4p. - Publication Year :
- 2005
-
Abstract
- <bold>Objective: </bold>The study aimed to assess the antidepressant efficacy and tolerability of adjunctive ropinirole in outpatients with treatment-resistant depression (TRD).<bold>Method: </bold>The study sample consisted of patients with a major depressive episode (diagnosed according to DSM-IV criteria) and TRD. Ropinirole 0.25 to 1.5 mg daily was added to tricyclic antidepressants or selective serotonin reuptake inhibitors. We conducted assessments at baseline and at weeks 2, 4, 8, 12, and 16. We defined response as a 50% or greater reduction of the Montgomery-Asberg Depression Rating Scale (MADRS) total score plus a score of 1 ("very much improved") or 2 ("much improved") on the Clinical Global Impression of Improvement scale at endpoint. Tolerability was monitored with the Dosage Record Treatment Emergent Symptom Scale.<bold>Results: </bold>Seven patients had major depressive disorder, and 3 had bipolar II disorder. The mean maximum dose of ropinirole was 1.33 mg daily. Mean (SD) scores on the MADRS decreased from 29.6 (7.6) at baseline to 16.9 (12.1) at endpoint (P < 0.02). At endpoint, 4 of 10 (40%) patients were responders. Two patients discontinued ropinirole because of dizziness.<bold>Conclusions: </bold>These pilot data suggest that, in selected cases of TRD, ropinirole augmentation of antidepressants is effective and relatively well tolerated. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ROPINIROLE
*MENTAL depression
*ANTIDEPRESSANTS
*SEROTONIN uptake inhibitors
*DIZZINESS
*NEUROLOGIC manifestations of general diseases
*DIAGNOSIS of mental depression
*DOPAMINE agonists
*INDOLE compounds
*CLINICAL trials
*COMPARATIVE studies
*DRUG resistance
*RESEARCH methodology
*MEDICAL cooperation
*CLASSIFICATION of mental disorders
*PSYCHOLOGICAL tests
*RESEARCH
*PILOT projects
*EVALUATION research
*SEVERITY of illness index
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 07067437
- Volume :
- 50
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Canadian Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17244312
- Full Text :
- https://doi.org/10.1177/070674370505000612