Intra-patient evolution of tumor microenvironment in the pathogenesis of treatment-naïve metastatic melanoma patients.

The article focuses on the intra-patient evolution of the tumor microenvironment (TME) in treatment-naive metastatic melanoma patients. Topics discussed include the heterogeneity of TME between primary and metastatic tumors, differential gene expression profiles, and the potential implications for predicting immunotherapy responsiveness.