心脏代谢损伤与适应性代偿在心力衰竭 发生发展中的作用.

Fatty acids, glucose, ketone bodies, and amino acids, arc utilized by the heart to meet its energy requirements, with fatty acids being the main source of energy. The damage of fatty acids oxidation is accompanied by heart failure. Cardiac metabolic remodeling occurs, wherein the heart utilizes glucose, ketone bodies, and other substances as energy substrates instead of fatty acid to meet its energetic requirements. Although this compensatory adaptation can improve energy deficiency-induced cardiac dysfunction, the metabolic balance of cardiomyocytcs can also he affected, thereby increasing the risk of cardiac dysfunction. This review summarizes the cardiac metabolic changes that occur during heart failure and the effects of cardiac metabolism nianipulation oil heart failure. It also explores the possibility of cardiac metabolic remodeling as a treatment for heart failure. [ABSTRACT FROM AUTHOR]