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Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis.

Authors :
Xia, Yu-ting
Zhang, Yu-qin
Chen, Lu
Min, Liangliang
Huang, Da
Zhang, Yulu
Li, Cong
Li, Zhi-hua
Source :
PLoS ONE. 9/26/2023, Vol. 18 Issue 9, p1-12. 12p.
Publication Year :
2023

Abstract

As one of the triterpene extracts of Taraxacum, a traditional Chinese plant, taraxerol (TRX) exhibits antitumor activity. In this study, we evaluated the effects of TRX on the migration and invasion of MDA-MB-231 cells, analyzed the molecular mechanism through network pharmacology and molecular docking, and finally verified it by in vitro experiments. The results showed that TRX could inhibit the migration and invasion of MDA-MB-231 cells in a time- and concentration-dependent manner, while MAPK3 was the most promising target and could stably combine with TRX. In addition, the relative protein expression levels were detected by Western blot, and we observed that TRX could inhibit the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. Moreover, an ERK activator (tert-butylhydroquinone, tBHQ) partially reversed the suppressive effect of TRX on MDA-MB-231 cells. In conclusion, TRX inhibited the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
18
Issue :
9
Database :
Academic Search Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
172349442
Full Text :
https://doi.org/10.1371/journal.pone.0291693