Carbon‐Sulfur Bond Formation via Ipso Nucleophilic Substitution of Electron‐Deficient Benzenesulfonic Acid with Thiol.

Developing green and convenient strategies for constructing C−S bonds is attractive, as it is indispensable for numerous essential biological and pharmaceutical compound syntheses. Herein, an efficient, cost‐effective method for synthesizing 2,4‐dinitroaryl thioether derivatives is achieved by ipso nucleophilic substitution of an aromatic sulfonic acid group by thiol to construct a new C−S bond. This methodology neither requires the assistance of any transition metal catalyst nor harsh reaction conditions. Such thioether formation from aryl sulfonic acids is new. [ABSTRACT FROM AUTHOR]