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Fluorescent probe based on acyclic cucurbituril to detect Fe3+ ions in living cells.
- Source :
-
Journal of Molecular Liquids . Nov2023:Part A, Vol. 390, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- [Display omitted] • A novel Py-ACB is firstly successfully prepared as fluorescent probe for Fe3+. • The probe Py-ACB possessed high selectivity and response speed to Fe3+. • The LOD of the probe for Fe3+ are 2.51 × 10−8 M. • The probe can be used to detect Fe3+ in living cells. Fe3+ is an essential element for human body, misregulation of which in cell are concerned with serious diseases. It is very meaningful to detect Fe3+ in living cells. Here, a novel fluorescent probe (Py-ACB) based on acyclic cucurbituril and pyrene was synthesized. Py-ACB exhibits high selectivity and sensitivity to Fe3+, Fe3+ is coordinated with the carbonyl groups and oxygen atoms of Py-ACB, resulting in reverse photo-induced electron transfer (reverse PET) from pyrene unit to the carbonyl oxygen atoms to induce fluorescence quenching. The binding constant and detection limits of Fe3+ recognized by Py-ACB are 9.26 × 104 M−1 and 2.51 × 10−8 M, respectively, and Py-ACB showed high response speed to Fe3+. More importantly, the probe Py-ACB showed strong fluorescence emission in living cell, which allowed the detection of Fe3+ in live cells by bioimaging. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01677322
- Volume :
- 390
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Liquids
- Publication Type :
- Academic Journal
- Accession number :
- 172326089
- Full Text :
- https://doi.org/10.1016/j.molliq.2023.122942