Sensory hypersensitivities are associated with post‐traumatic headache‐related disability.

Objective: To examine whether sensory hypersensitivity contributes to headache‐related disability in a secondary analysis of patients with post‐traumatic headache. Background: Up to one‐third of individuals with traumatic brain injuries report persistent headache 3 months post‐injury. High rates of allodynia and photophobia have been observed in clinical studies and animal models of post‐traumatic headache, but we do not fully understand how sensory amplifications impact post‐traumatic headache‐related disability. Methods: We identified a cross‐sectional sample of patients from the American Registry for Migraine Research database with new or worsening headaches post‐head injury from 2016 to 2020 and performed a secondary analysis of those data. We modeled the relationship between sensory sensitivity and Migraine Disability Assessment scores using questionnaires. Candidate variables included data collection features (study site and year), headache‐related and general clinical features (headache frequency, migraine diagnosis, abuse history, sex, age, cognitive and affective symptom scores), and sensory symptoms (related to light, sound, and touch sensitivity). Results: The final sample included 193 patients (median age 46, IQR 22; 161/193, 83.4% female). Migraine Disability Assessment scores ranged from 0 to 260 (median 47, IQR 87). The final model included allodynia, hyperacusis, photosensitivity, headache days per month, abuse history, anxiety and depression, cognitive dysfunction, and age (R2 = 0.43). An increase of one point in allodynia score corresponded to a 3% increase in headache disability (95% CI: 0%–7%; p = 0.027), an increase of one‐tenth of a point in the photosensitivity score corresponded to a 12% increase (95% CI: 3%–25%; p = 0.002), and an increase of one point in the hyperacusis score corresponded to a 2% increase (95% CI: 0%–4%; p = 0.016). Conclusions: Increased photosensitivity, allodynia, and hyperacusis were associated with increased headache‐related disability in this sample of patients with post‐traumatic headache. Symptoms of sensory amplification likely contribute to post‐traumatic headache‐related disability and merit an ongoing investigation into their potential as disease markers and treatment targets. [ABSTRACT FROM AUTHOR]