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Autoinmunidad y clasificación de Freiburg en pacientes con inmunodeficiencia común variable.
- Source :
-
Revista Medica del IMSS . 2023 Supplement, pS484-S491. 8p. - Publication Year :
- 2023
-
Abstract
- Introduction: Up to 25% of patients with common variable immunodeficiency (CVID) debut with autoimmunity, which is related to the Freiburg classification, which is based on flow cytometry. Objective: to determine the frequency and type of autoimmune diseases and their association with the Freiburg classification in adults with CVID. Material and methods: A cross-sectional, analytical and observational study was carried out with 33 patients belonging to the Primary Immunodeficiency Clinic of a third level hospital, with a diagnosis of CVID. They were divided into 3 phenotypes according to the Freiburg classification. Results: Of the 33 patients studied, 66.6% presented autoimmune diseases, 19 of them (86.3%) had cytopenia; 42.1% belonged to Freiburg group Ia, 36.8% to Ib and 21% to phenotype II. In 36.6% of the patients, autoimmune cytopenia were the first manifestation of CVID; and up to 70% of them belong to the Freiburg phenotype Ia (p = 0.086). Patients with autoimmune cytopenia had a lower percentage of isotype-switched memory B cells (p = 0.018), no higher percentage of CD21low B cells (p = 0.226). Conclusions: Classification by CVID phenotypes allows the identification of the patient's profile according to the percentage of memory B cells with isotype change, which is useful to intentionally search for non-infectious complications of the disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Spanish
- ISSN :
- 04435117
- Database :
- Academic Search Index
- Journal :
- Revista Medica del IMSS
- Publication Type :
- Academic Journal
- Accession number :
- 172011662
- Full Text :
- https://doi.org/10.5281/zenodo.8319786