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General Synthesis of 3‐Azabicyclo[3.1.1]heptanes and Evaluation of Their Properties as Saturated Isosteres.
- Source :
-
Angewandte Chemie International Edition . 9/25/2023, Vol. 62 Issue 39, p1-8. 8p. - Publication Year :
- 2023
-
Abstract
- A general approach to 3‐azabicyclo[3.1.1]heptanes by reduction of spirocyclic oxetanyl nitriles was developed. The mechanism, scope, and scalability of this transformation were studied. The core was incorporated into the structure of the antihistamine drug Rupatidine instead of the pyridine ring, which led to a dramatic improvement in physicochemical properties. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPTANE
*PYRIDINE
*SCALABILITY
*ANTIHISTAMINES
*PENTANE
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 39
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 171998895
- Full Text :
- https://doi.org/10.1002/anie.202304246