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Green Synthesis of Novel [1,3,4]Thiadiazolo[3,2-a]Pyrimidines via Three-Component Reaction of 5-Amino-1,3,4-Thiadiazole-2-Thiol, Aromatic Aldehydes, and Meldrum's Acid.
- Source :
-
Polycyclic Aromatic Compounds . 2023, Vol. 43 Issue 8, p7343-7354. 12p. - Publication Year :
- 2023
-
Abstract
- A novel and highly efficient synthetic route to [1,3,4]thiadiazolo[3,2-a]pyrimidine derivatives from 5-amino-1,3,4-thiadiazole-2-thiol, various aromatic aldehydes, and Meldrum's acid in the presence of acetic acid in dry ethanol has been reported. We designed the three-component reaction with the incorporation of Knoevenagel condensation followed by an intermolecular nucleophilic addition reaction in one pot under mild conditions. The structural diversities of these synthesized compounds have been confirmed spectroscopically, by IR, 1H-, and 13C NMR, and elemental analysis, which agree with the proposed structures. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10406638
- Volume :
- 43
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Polycyclic Aromatic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 171996048
- Full Text :
- https://doi.org/10.1080/10406638.2022.2150654