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Rho-kinase inhibitors to deplete age-associated B cells in systemic autoimmunity.
- Source :
-
Immunology Letters . Oct2023, Vol. 262, p36-38. 3p. - Publication Year :
- 2023
-
Abstract
- • Age-associated B cells (ABCs) are considered as drivers of autoimmune disease pathogenesis. • SWEF proteins (DEF6 and SWAP-70) regulate ABCs, via a mechanism involving IRF5 and IL-21. • Lack of DEF6 and/or SWAP-70 leads to increased Rho-kinase (ROCK) activity in immune cells. • ROCK inhibitors may deplete ABCs, thus contribute to autoimmune disease management and therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01652478
- Volume :
- 262
- Database :
- Academic Search Index
- Journal :
- Immunology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 171992741
- Full Text :
- https://doi.org/10.1016/j.imlet.2023.09.004