Rho-kinase inhibitors to deplete age-associated B cells in systemic autoimmunity.

• Age-associated B cells (ABCs) are considered as drivers of autoimmune disease pathogenesis. • SWEF proteins (DEF6 and SWAP-70) regulate ABCs, via a mechanism involving IRF5 and IL-21. • Lack of DEF6 and/or SWAP-70 leads to increased Rho-kinase (ROCK) activity in immune cells. • ROCK inhibitors may deplete ABCs, thus contribute to autoimmune disease management and therapy. [ABSTRACT FROM AUTHOR]