CuCl2‐Catalyzed one‐step protocol for the synthesis of novel propargylamine analogs under ultrasound irradiation.

In this work, twenty new polysubstituted propargylamine analogs were produced in good to excellent yields via one‐step reaction of alkynes, aromatic aldehydes, and cyclic secondary amines using CuCl2 in DMF under ultrasound irradiation at 80 °C. Twelve compounds having both quinazoline building block and propargylamine scaffolds were synthesized. [ABSTRACT FROM AUTHOR]