Harnessing actinobacteria potential for cancer prevention and treatment.

Actinobacteria are gram-positive bacteria with high G:C ratio in their genetic makeup. They have been noted and studied for their capacity to produce bioactive substances with a range of uses in human health, and they also exhibit a unique property of adapting to extreme environments quite well. Actinobacteria may play an essential role in cancer prevention and treatment due to their synthesis of anticancer compounds, as indicated by recent studies. The aim of this review is to give a summary of what is currently known about the connection between actinobacteria and different types of cancer. This paper delineates the diverse array of actinobacterial bioactive compounds possessing anticancer properties, elucidates their mechanisms of action and explores potential applications in cancer treatment. Furthermore, this review highlights how the microbiome influences the onset and progression of cancer, as well as the discussing the potential benefits that actinobacteria may bring in terms of controlling the microbiome and contributing to the regulation of the tumour microenvironment to cure or prevent cancer. [Display omitted] • Actinobacteria are a rich source of natural secondary metabolites with potent anticancer and cytotoxicity properties. • The presence of actinobacteria in tumour micro environment is highly influential in tumour development as well as inhibition. • Actinobacterial derived compounds offer the potential for targeted therapies for inhibiting key molecular pathway. • Actinobacteria derived compounds suggest the potential for personalized medicine approaches in cancer treatment. [ABSTRACT FROM AUTHOR]