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CD155 and its receptors in cancer immune escape and immunotherapy.

Authors :
Zhou, Ruijia
Chen, Shiyin
Wu, Qiwen
Liu, Lingyun
Wang, Yian
Mo, Yongzhen
Zeng, Zhaoyang
Zu, Xuyu
Xiong, Wei
Wang, Fuyan
Source :
Cancer Letters. Oct2023, Vol. 573, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

In recent years, there have been multiple breakthroughs in cancer immunotherapy, with immune checkpoint inhibitors becoming the most promising treatment strategy. However, available drugs are not always effective. As an emerging immune checkpoint molecule, CD155 has become an important target for immunotherapy. This review describes the structure and function of CD155, its receptors TIGIT, CD96, and CD226, and summarizes that CD155 expressed by tumor cells can upregulate its expression through the DNA damage response pathway and Ras-Raf-MEK-ERK signaling pathway. This review also elaborates the mechanism of immune escape after binding CD155 to its receptors TIGIT, CD96, and CD226, and summarizes the current progress of immunotherapy research regarding CD155 and its receptors. Besides, it also discusses the future direction of checkpoint immunotherapy. • Cancer immunotherapy is a promising therapeutic approach in clinical oncology. • CD155 is highly expressed in a variety of tumors. • CD155 binds to its receptors TIGIT, CD96, and CD226, leading to immune escape. • CD155 can be used as an important potential therapeutic target. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043835
Volume :
573
Database :
Academic Search Index
Journal :
Cancer Letters
Publication Type :
Academic Journal
Accession number :
171952900
Full Text :
https://doi.org/10.1016/j.canlet.2023.216381