Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review.

[Display omitted] • The pharmaceutical significance of imidazopyridines is described. • The importance of kinases in cellular processes and their structures are presented. • The role of kinases in the cancer treatment is explained. • The comprehensive review about imidazopyridines as kinase inhibitors are provided. • The substantial structural features and interactions of imidazopyridines against these kinases are thoroughly described. Considering the fundamental role of protein kinases in the mechanism of protein phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has underscored their therapeutic relevance. Imidazopyridines represent versatile scaffolds found in abundant bioactive compounds. Given their structural features, imidazopyridines have possessed pivotal potency to interact with different protein kinases, inspiring researchers to carry out numerous structural variations. In this comprehensive review, we encompass an extensive survey of the design and biological evaluations of imidazopyridine-based small molecules as potential agents targeting diverse kinases for anticancer applications. We describe the structural elements critical to inhibitory potency, elucidating their key structure–activity relationships (SAR) and mode of actions, where available. We classify these compounds into two groups: Serine/threonine and Tyrosine inhibitors. By highlighting the promising role of imidazopyridines in kinase inhibition, we aim to facilitate the design and development of more effective, targeted compounds for cancer treatment. [ABSTRACT FROM AUTHOR]