Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival.

First, we analyzed 360 anatomically defined glioblastoma regions of interest by spatial immune profiling utilizing a panel of 28 DNA bar-coded antibodies to quantify immune cell types and immunotherapy targets in perivascular, perinecrotic and cell-dense tumor regions (Fig. Prominent and disease-defining histopathologic features of glioblastoma, the most common type of glioma, include microvascular proliferation and necrosis, the latter often with perinecrotic palisading of tumor cells [[3]]. [Extracted from the article]