Maximum likelihood estimation in the additive hazards model.

The additive hazards model specifies the effect of covariates on the hazard in an additive way, in contrast to the popular Cox model, in which it is multiplicative. As the non‐parametric model, additive hazards offer a very flexible way of modeling time‐varying covariate effects. It is most commonly estimated by ordinary least squares. In this paper, we consider the case where covariates are bounded, and derive the maximum likelihood estimator under the constraint that the hazard is non‐negative for all covariate values in their domain. We show that the maximum likelihood estimator may be obtained by separately maximizing the log‐likelihood contribution of each event time point, and we show that the maximizing problem is equivalent to fitting a series of Poisson regression models with an identity link under non‐negativity constraints. We derive an analytic solution to the maximum likelihood estimator. We contrast the maximum likelihood estimator with the ordinary least‐squares estimator in a simulation study and show that the maximum likelihood estimator has smaller mean squared error than the ordinary least‐squares estimator. An illustration with data on patients with carcinoma of the oropharynx is provided. [ABSTRACT FROM AUTHOR]