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What is the impact of stress on the onset and anti-thyroid drug therapy in patients with graves' disease: a systematic review and meta-analysis.
- Source :
-
BMC Endocrine Disorders . 9/12/2023, Vol. 23 Issue 1, p1-10. 10p. - Publication Year :
- 2023
-
Abstract
- Background: The effect of stress on Graves' disease (GD) is controversial. Our purpose was to quantify the impacts of stress on patients with Graves' disease. Methods: Systematic searches of PubMed, MEDLINE, Embase, Web of Science, Scopus, Cochrane Library and PsycInfo were conducted from inception to 1 January 2023. Studies comparing the incidence of stressful life events (SLEs) that occurred before diagnosis and during drug therapy in cases diagnosed with GD and controls were included in the final analysis. Results: Nine case-control studies and four cohort studies enrolling 2892 participants (1685 [58%] patients) were included. Meta-analysis revealed a high and significant effect-size index in a random effect model (d = 1.81, P = 0.01), indicating that stress is an important factor in the onset of GD. The relationship between SLEs and GD was stronger in studies with higher proportions of female patients (β = 0.22, P < 0.01) and weaker in studies with older patients with GD (β =−0.62, P < 0.01). However, stress did not significantly affect the outcome of antithyroid drug therapy for GD (d = 0.32, P = 0.09). Conclusions: The results of this meta-analysis suggest that stress is one of the environmental triggers for the onset of GD. Therefore, we recommend stress management assistance for individuals genetically susceptible to GD, especially for young females. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENDOCRINOLOGY
*ONLINE information services
*MEDICAL databases
*PSYCHOLOGY information storage & retrieval systems
*META-analysis
*MEDICAL information storage & retrieval systems
*SYSTEMATIC reviews
*GRAVES' disease
*SEX distribution
*DESCRIPTIVE statistics
*RESEARCH funding
*THYROID antagonists
*MEDLINE
*STATISTICAL models
*PSYCHOLOGICAL stress
*ENVIRONMENTAL exposure
*THYROID gland
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 23
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 171897424
- Full Text :
- https://doi.org/10.1186/s12902-023-01450-y